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一次性技术 1

光学活检 1

共聚焦内窥镜 1

分流测量 1

双目内窥镜；三维测量；深度学习；视差预测 1

大力传感器 1

微小型生物反应器 1

支承式 1

新一代生物工艺研发与生物制造技术 1

烈性传染病 1

电阻应变计 1

精准医学 1

细胞分辨率 1

重型装备 1

附着式 1

高通量技术 1

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Analysis of actuating mechanics characteristics for a flexible miniature robot system

YU Lianzhi, YAN Guozheng, MA Guanying, ZAN Peng

《机械工程前沿（英文）》 2008年第3卷第1期页码 66-70 doi: 10.1007/s11465-008-0006-5

摘要： Based on the inchworm movement, a miniature endoscope inspection robot system with a flexible structure is designed. The system is actuated by a pneumatic rubber actuator with three degrees of freedom, and it holds its position by air chambers. The actuating mechanics characteristics of the robot are analyzed. An electro-pneumatic pressure system is designed to control the motion of the robot. Results of the calculation and experiments are consistent, and the robot system can move smoothly in a soft tube.

关键词： calculation consistent endoscope inspection electro-pneumatic miniature endoscope

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An autonomous miniature wheeled robot based on visual feedback control

CHEN Haichu

《机械工程前沿（英文）》 2007年第2卷第2期页码 197-200 doi: 10.1007/s11465-007-0033-7

摘要： Using two micro-motors, a novel omni-direction miniature wheeled robot is designed on the basis of the bi-corner driving principle. The robot takes advantage of the Bluetooth technology to wirelessly transmit data at a short distance. Its position and omni-direction motion are precise. A Charge Coupled Device (CCD) camera is used for measuring and for visual navi gation. A control system is developed. The precision of the position is 0.5 mm, the resolution is about 0.05 mm, and the maximum velocity is about 52 mm/s. The visual navigation and control system allow the robot to navigate and track the target and to accomplish autonomous locomotion.

关键词： measuring distance autonomous locomotion advantage navigation

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Development of mobile miniature natural gas liquefiers

Yanxing ZHAO, Maoqiong GONG, Haocheng WANG, Hao GUO, Xueqiang DONG

《能源前沿（英文）》 2020年第14卷第4期页码 667-682 doi: 10.1007/s11708-020-0695-y

摘要： With increasing consumption of natural gas (NG), small NG reservoirs, such as coalbed methane and oil field associated gas, have recently drawn significant attention. Owing to their special characteristics (e.g., scattered distribution and small output), small-scale NG liquefiers are highly required. Similarly, the mixed refrigerant cycle (MRC) is suitable for small-scale liquefaction systems due to its moderate complexity and power consumption. In consideration of the above, this paper reviews the development of mobile miniature NG liquefiers in Technical Institute of Physics and Chemistry (TIPC), China. To effectively liquefy the scattered NG and overcome the drawbacks of existing technologies, three main improvements, i.e., low-pressure MRC process driven by oil-lubricated screw compressor, compact cold box with the new designed heat exchangers, and standardized equipment manufacturing and integrated process technology have been made. The development pattern of “rapid cluster application and flexible liquefaction center” has been eventually proposed. The small-scale NG liquefier developed by TIPC has reached a minimum liquefaction power consumption of about 0.35 kW·h/Nm . It is suitable to exploit small remote gas reserves which can also be used in boil-off gas reliquefaction and distributed peak-shaving of pipe networks.

关键词： natural gas mobile miniature liquefiers mixed refrigerant cycle vapor liquid equilibrium heat transfer

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A miniature triaxial apparatus for investigating the micromechanics of granular soils with

Zhuang CHENG, Jianfeng WANG, Matthew Richard COOP, Guanlin YE

《结构与土木工程前沿（英文）》 2020年第14卷第2期页码 357-373 doi: 10.1007/s11709-019-0599-2

摘要： The development of a miniature triaxial apparatus is presented. In conjunction with an X-ray micro-tomography (termed as X-ray μCT hereafter) facility and advanced image processing techniques, this apparatus can be used for investigation of the micro-scale mechanical behavior of granular soils under shear. The apparatus allows for triaxial testing of a miniature dry sample with a size of (diameter height). triaxial testing of a 0.4–0.8 mm Leighton Buzzard sand (LBS) under a constant confining pressure of 500 kPa is presented. The evolutions of local porosities (i.e., the porosities of regions associated with individual particles), particle kinematics (i.e., particle translation and particle rotation) of the sample during the shear are quantitatively studied using image processing and analysis techniques. Meanwhile, a novel method is presented to quantify the volumetric strain distribution of the sample based on the results of local porosities and particle tracking. It is found that the sample, with nearly homogenous initial local porosities, starts to exhibit obvious inhomogeneity of local porosities and localization of particle kinematics and volumetric strain around the peak of deviatoric stress. In the post-peak shear stage, large local porosities and volumetric dilation mainly occur in a localized band. The developed triaxial apparatus, in its combined use of X-ray μCT imaging techniques, is a powerful tool to investigate the micro-scale mechanical behavior of granular soils.

关键词： triaxial apparatus X-ray μCT in situ test micro-scale mechanical behavior granular soils

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Cavitation in semi-open centrifugal impellers for a miniature pump

LUO Xianwu, LIU Shuhong, ZHANG Yao, XU Hongyuan

《能源前沿（英文）》 2008年第2卷第1期页码 31-35 doi: 10.1007/s11708-008-0011-8

摘要： Cavitation in miniature pumps was investigated experimentally for two semi-open centrifugal impellers. Although both impellers had the same blade cross-section, one impeller had a two-dimensional blade, while the other had a leaned blade. The flows were also analyzed using a numerical model of the three-dimensional turbulent flow in the pumps near the peak efficiency point using the -? turbulence model and the VOF cavitation model. The average cavitation performance of each impeller was satisfactorily predicted by the numerical simulations. The results show that the miniature pumps have similar cavitation performances as an ordinary-size pump, with the cavitation performance of the semi-open impeller reduced by increased axial tip clearances. Also, both the hydraulic and cavitation performance of the semi-open impeller were improved by the leaned blade. The results also show that uniform flow upstream of the impeller inlet will improve the cavitation performance of a miniature pump.

关键词： cavitation performance semi-open impeller increased two-dimensional efficiency

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Application of endoscopic techniques in orbital blowout fractures

null

《医学前沿（英文）》 2013年第7卷第3期页码 328-332 doi: 10.1007/s11684-013-0271-5

摘要：

Minimally invasive surgical techniques, particularly endoscopic techniques, have revolutionized otolaryngeal surgery. Endoscopic techniques have been gradually applied in orbital surgery through the sinus inferomedial to the orbit and the orbital subperiosteal space. Endoscopic techniques help surgeons observe fractures and soft tissue of the posterior orbit to precisely place implants and protect vital structures through accurate, safe, and minimally invasive approaches. We reviewed the development of endoscopic techniques, the composition of endoscopic systems for orbital surgery, and the problems and developmental prospects of endoscopic techniques for simple orbital wall fracture repair.

关键词： orbital fractures endoscope restoration surgery

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A Miniature Meta-Optical System for Reconfigurable Wide-Angle Imaging and Polarization-Spectral Detection

Fei Zhang,Minghao Liao,Mingbo Pu,Yinghui Guo,Lianwei Chen,Xiong Li,Qiong He,Tongtong Kang,Xiaoliang Ma,Yuan Ke,Xiangang Luo,

《工程（英文）》 doi: 10.1016/j.eng.2023.07.008

摘要： Wide-angle imaging and spectral detection play vital roles in tasks such as target tracking, object classification, and anti-camouflage. However, limited by their intrinsically different architectures, as determined by frequency dispersion requirements, their simultaneous implementation in a shared-aperture system is difficult. Here, we propose a novel concept to realize reconfigurable dual-mode detection based on electrical-control tunable metasurfaces. As a proof-of-concept demonstration, the simultaneous implementation of wide-angle imaging and polarization-spectral detection in a miniature shared-aperture meta-optical system is realized for the first time via the electrical control of cascaded catenary-like metasurfaces. The proposed system supports the imaging (spectral) resolution of approximately 27.8 line-pairs per millimeter (lp·mm⁻¹; ∼80 nm) for an imaging (spectral) mode from 8 to 14 μm. This system also bears a large field of view of about 70°, enabling multi-target recognition in both modes. This work may promote the miniaturization of multifunctional optical systems, including spectrometers and polarization imagers, and illustrates the potential industrial applications of meta-optics in biomedicine, security, space exploration, and more.

关键词： Metasurfaces Reconfigurable Imaging Spectral

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新一代生物工艺研发与制造技术及高通量微小型生物反应器

焦鹏,陈必强

《中国工程科学》 2016年第18卷第4期页码 44-50 doi: 10.15302/J-SSCAE-2016.04.007

摘要：

近些年，人们认识到快速反应时间对应对烈性传染病具有至关重要的作用，然而传统工艺和技术无法有效应对。以美国卫生部为代表的机构提出并开始践行新一代工艺研发与生物制造的技术平台，其目的是要极大缩短生物工艺研发和生产的周期，从而快速应对。精准医学的发展对医药研发与生产也提出了产品研发制备周期短、种类增加、数量减少的新要求，需要新一代的研发与生产技术。实现快速研发的核心设备是微小型生物反应器，新一代技术核心包括高通量筛选、高通量工艺研发，一次性技术，模块化及柔性化生产。新一代工艺研发与生物制造技术不仅关系到国家安全、人民生命健康，其作用及影响将辐射到整个生物加工制造领域，社会与经济价值巨大。

关键词：新一代生物工艺研发与生物制造技术烈性传染病精准医学微小型生物反应器高通量技术一次性技术

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Capsule endoscopy—A mechatronics perspective

Lin LIN, Mahdi RASOULI, Andy Prima KENCANA, Su Lim TAN, Kai Juan WONG, Khek Yu HO, Soo Jay PHEE

《机械工程前沿（英文）》 2011年第6卷第1期页码 33-39 doi: 10.1007/s11465-011-0203-5

摘要：

The recent advances in integrated circuit technology, wireless communication, and sensor technology have opened the door for development of miniature medical devices that can be used for enhanced monitoring and treatment of medical conditions. Wireless capsule endoscopy is one of such medical devices that has gained significant attention during the past few years. It is envisaged that future wireless capsule endoscopies replace traditional endoscopy procedures by providing advanced functionalities such as active locomotion, body fluid/tissue sampling, and drug delivery. Development of energy-efficient miniaturized actuation mechanisms is a key step toward achieving this goal. Here, we review some of the actuators that could be integrated into future wireless capsules and discuss the existing challenges.

关键词： wireless capsule endoscopy ingestible medical device in-body medical device medical robot miniature actuator

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用于细胞成像的共聚焦内窥镜 Article

王家福,杨敏,杨莉,张云,袁菁,刘谦,侯晓华,付玲

《工程（英文）》 2015年第1卷第3期页码 351-360 doi: 10.15302/J-ENG-2015081

摘要：

使用内窥镜的目的是实现与组织病理诊断相符的即时诊断。在过去的十年里，共聚焦激光扫描显微成像技术被引入内窥镜领域。共聚焦内窥镜使得对活体组织的显微观察能够达到与组织学样品的体外显微成像相当的放大倍数和分辨率。发展这种内窥镜的主要挑战在于具有微米级分辨率的显微成像光纤探头的小型化。笔者研制了一套基于光纤束，分辨率为1.4 μm，成像速度可达8 fps的共聚焦内窥镜系统。光纤探头的直径为2.6 mm，可与常规内窥镜的活检通道兼容。该共聚焦内窥镜的样机已经被用于观察小鼠胃肠道上皮细胞，并将进一步被用于临床试验。此外，该共聚焦内窥镜能够被用于上皮细胞功能的转化研究，以监测自然生理环境中细微颗粒的功能和细胞间的相互作用。

关键词：细胞分辨率共聚焦内窥镜光学活检

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基于深度学习的双目内窥镜三维测量方法 Research Article

余浩1,周长江2,张伟1,王立强1,2,杨青1,2,袁波1

《信息与电子工程前沿（英文）》 2022年第23卷第4期页码 653-660 doi: 10.1631/FITEE.2000679

摘要：在内窥镜临床检查中，病灶尺寸精确估计对诊断具有非常重要的意义。本文提出一种基于深度学习的双目内窥镜三维测量方法，可以克服传统双目匹配算法在弱纹理区域鲁棒性较差的缺点。利用三维扫描仪获得的目标三维数据和三维渲染软件仿真的双目相机创建虚拟双目图像数据集，用于训练视差预测模型进行三维测量。实验结果表明，所提方法相比传统双目匹配算法在视差准确度和视差图生成速度上分别提高48.9%和90.5%，能够提供更加准确、可靠的病灶尺寸信息，提高内窥镜诊断效率。

关键词：双目内窥镜；三维测量；深度学习；视差预测

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大力测量技术的新进展——附着式超轻型大力传感器

沈久珩

《中国工程科学》 2001年第3卷第10期页码 22-27

摘要：

大力传感器是现代重型装备的高科技电子信息器件。文章围绕重型大力传感器的微型化问题论述了重型装备大力测量的意义、特征及发展，讨论了大力分流测量的物理模型，介绍了作者发明的超轻型附着式大力传感器及其工程应用。

关键词：重型装备大力传感器支承式附着式电阻应变计分流测量

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Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

《机械工程前沿（英文）》 2011年第6卷第1期页码 40-44 doi: 10.1007/s11465-011-0204-4

摘要：

Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinal tract. This method offers a less-invasive alternative to traditional endoscopy by eliminating uncomfortable procedures of the traditional endoscopy. Moreover, it provides the opportunity for exploring inaccessible areas of the small intestine. Current capsule endoscopes, however, move by peristalsis and are not capable of detailed and on-demand inspection of desired locations. Here, we propose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal disorders. The vision systems in these capsules are equipped with mechanical actuators to adjust the position of the camera. This may help to cover larger areas of the digestive tract and investigate desired locations. The preliminary experimental results showed that the developed platform could successfully communicate with the external control unit via human body and adjust the position of camera to limited degrees.

关键词： wireless capsule endoscopy ingestible medical device in-body medical device miniature actuator medical robot medical imaging